About
Bioregulatory
Systems Medicine
Initiative
Bioregulatory Systems Medicine (BrSM) is a specialized application of systems medicine that retains its view of the human body as an integrated whole — a dynamic network of interconnected systems influenced by factors like genetics, environment, and lifestyle. Building on this foundation, BrSM adds a unique focus: restoring the body’s natural ability to self-regulate (autoregulation) by addressing underlying imbalances in local and systemic molecular regulation (molecular networks). Using multicomponent, multitarget medications, BrSM aims to rebalance these dysregulated networks. The goal is holistic, sustainable health through enhancing the body's own regulating mechanisms, integrating cutting-edge science, advanced diagnostic tools and personalized care.
Scientists and clinicians from various backgrounds developed the concept
The concept of Bioregulatory Systems Medicine was developed by an international team of scientific and clinical experts from various backgrounds. Scientific experts included those in the fields of immunology, neuroscience, genomics, molecular biology, systems biology, and systems medicine. Clinical experts included physicians who specialize in various medical areas including family and community medicine, chronic diseases, aging, cardiology, pediatrics and neurology.
The BrSM Initiative was launched in 2008 through an initial meeting of global medical experts in collaboration with experts in bioregulatory medicine from Heel.
An integrated and cohesive model of this approach was developed
The team set out systematically to bring together those elements critical to Bioregulatory Systems Medicine, and to conceptualize an integrated, cohesive model of this approach. More than forty individuals participated in the development of the model. The initiative was led by a core team of international experts and clinicians with different medical backgrounds. The combination of these heterogeneous perspectives helped to ensure that the emerging conceptual model would represent a consensus understanding of Bioregulatory Systems Medicine that would resonate with a broad group of scientists and clinicians globally.
Outlook
The purpose of the model development was to realize and articulate relationships among the scientific and clinical elements of Bioregulatory Systems Medicine. Whereas the practical and theoretical implications of the model have been discussed, the implementation of the model in the clinical context needs to be further elaborated. The development and integration of formal diagnostics and the ongoing growth of a scientific and clinical community will be at the center of the future activities of the BrSM initiative.