Documents & Links

Relevant Publications

Scientific Publication

The open access, peer-reviewed publication presenting the Bioregulatory Systems Medicine concept in Frontiers in Physiology, Systems Biology section.

Barabási, Gulbahce and Loscalzo Nature Reviews 2011 Network Medicine: a network-based approach to human disease

The seminal publication presenting an overview of the organizing principles that govern cellular networks and their role in disease.

Csermely, Korcsmaros, Kiss et al Pharmacology & therapeutics 2013 Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

The comprehensive review explaining properties of biological networks and their use in describing human diseases and drug design strategy.

Bousquet, Anto, Sterk et al Genome Medicine 2011 Systems medicine and integrated care to combat chronic noncommunicable diseases

The seminal publication presenting a statement of international expert groups positing how noncommunicable disease management should move towards holistic multimodal integrated care, and multi-scale, multi-level systems approaches.

Ahn, Tewari, Poon et al PLOS Medicine 2006 The limits of reductionism in medicine: could systems biology offer an alternative?

The first publication in a widely-cited series of two articles where the authors examine the reductionist approach that pervades medicine and explains how a systems approach may complement it.

Ahn, Tewari, Poon et al PLOS Medicine 2006 The clinical applications of a systems approach

The second publication in a widely-cited series of two articles where the authors present a practical discussion of how a systems approach could be valuable for clinical medicine.

Useful Links

Institute for Systems Biology

The home page of the Institute for Systems Biology (ISB), a non-profit biomedical research organization based in Seattle, Washington. ISB was co-founded by systems biologist Leroy Hood, and is the world-renowned leading institution in systems biology research.

P4 Medicine Institute

The home page of the P4 Medicine Institute, a non-profit institution co-founded by the Institute for Systems Biology and The Ohio State University to help catalyze the transformation of healthcare systems to Predictive, Preventive, Personalized and Participatory (P4) Medicine.

CASYM Europe

The home page of Coordinating Action Systems Medicine (CASYM), a multidisciplinary European consortium that joined forces to develop an implementation strategy (road map) for Systems Medicine in Europe.

„The New Biology“ movie

This documentary film features the wave of cutting-edge technologies that now provide the opportunity to create predictive models of living systems, and gain wisdom about the fundamental nature of life itself.