Developing the BrSM model

In 2008, Heel convened the initial model development meeting with independent medical and scientific experts, in collaboration with experts in bioregulatory medicine from Heel. Four follow-up expert group round tables were conducted over the subsequent three years.

The objectives of these round tables were iterative inquiry of empirical experience in clinical practice, highlighting unmet medical needs and gaps in the current treatment paradigm. Meetings also included discussions and feedback on the latest trends in modern biomedicine, considering them through the lens of available preclinical and clinical research.

The outcome was an initial set of scientific and clinical topics as the basis for a data mining strategy. Topics included molecular biology, systems biology, systems medicine, P4 medicine, inflammation resolution, immunology, neuroscience, genomics, integrative medicine, chronic non-communicable diseases, multimorbidity and iatrogenesis. Particular emphasis was placed on systems biology and systems medicine as a modern science for explaining the complexity of human biology and disease.

Following these meetings, discussion content was summarized and a preliminary framework of the BrSM concept was developed.

The development process diagram is depicted in the figure below. Additional details are described in the White Paper.

Flow diagram of the development process

Flow diagram of the model development process.

The key steps in the process iteratively engaged HCPs and independent scientific experts by establishing the framework of expert group round tables, inquiring for feedback in almost each step, and using The Concept System© conceptualization algorithm to compute and visualize emergent consensus from a larger group of participants. The emergent conceptual model serves as a basis for research program development and further experimental validation.